Japanese Systemic Lupus Erythematosus and Major Histocompatibility Complex
نویسندگان
چکیده
منابع مشابه
Major Histocompatibility Complex Haplotypes and Complement C 4 Alleles in Systemic Lupus Erythematosus
In a multicenter study more than 300 central European systemic lupus erythematosus (SLE) patients were examined for HLA-B, HLA-DR, and complement C4 phenotypes. For 174 SLE patients MHC haplotypes were determined by family segregation analysis, and for 155 patients C4 gene deletions were determined by TaqI restriction fragment length polymorphism. Two haplotypes, B8-C4AQO-C4B1-DR3 and B7-C4A3-C...
متن کاملSystemic lupus erythematosus and the extended major histocompatibility complex--evidence for several predisposing loci.
OBJECTIVE Systemic lupus erythematosus (SLE) is an autoimmune disease reported to be associated with several alleles in the HLA complex. The purpose of this study was to systematically examine the extended HLA complex (xMHC) in order to get an overview of the primary predisposing genetic factors. MATERIALS AND METHODS One hundred and sixty-four SLE patients and 254 healthy, unrelated controls...
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Background: Brucellosis is a zoonotic infection which is endemic in many countries. It is a multisystem disease which may present with a broad spectrum of clinical manifestations and complications. Neurobrucellosis is an uncommon complication of brucellosis. Case presentation: A 25-year-old woman with a history of lupus for 5 months referred to the emergency ward of Shahid Beheshti Hosp...
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Systemic lupus erythematosus (SLE) is a multifactorial autoimmune disease which affects different organs and systems that, has a complex genetic inheritance, and is affected by both epigenetic and environmental risk factors. Previous studies on SLE have lacked the statistical power and genetic resolution to fully determine the influence of major histocompatibility complex (MHC) on SLE. In this ...
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ژورنال
عنوان ژورنال: Japanese Journal of Clinical Immunology
سال: 1987
ISSN: 0911-4300,1349-7413
DOI: 10.2177/jsci.10.240